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1

Pharmaceutical patents: reconciling the human right to health with the incentive to invent

Khachigian, Levon M.

Journal:

Drug Discovery Today

Year:

2020

File:

PDF, 321 KB

2020

2

RETRACTED: Related transcriptional enhancer factor-1 induces fibroblast growth factor receptor-1 expression in endothelial cells

Cuili Zhang, Q.H. Song, Levon M. Khachigian, I. Lubenec, Jue-Lon Shie, Baofeng Yang, Jian Li, Ye Tian

Journal:

Biochemical and Biophysical Research Communications

Year:

2009

Language:

english

File:

PDF, 549 KB

english, 2009

3

Drug-induced Immune Thrombocytopenia

Chong, Beng H., Young-Ill Choi, Philip, Khachigian, Levon, Perdomo, Jose

Journal:

Hematology/Oncology Clinics of North America

Year:

2013

Language:

english

File:

PDF, 962 KB

english, 2013

4

DNAzyme technology and cancer therapy: cleave and let die

Dass, C. R., Choong, P. F.M., Khachigian, L. M.

Journal:

Molecular Cancer Therapeutics

Year:

2008

Language:

english

File:

PDF, 374 KB

english, 2008

5

Corrigendum: Suppression of vascular permeability and inflammation by targeting of the transcription factor c-Jun

Fahmy, Roger G, Waldman, Alla, Zhang, Guishui, Mitchell, Ainslie, Tedla, Nicodemus, Cai, Hong, Geczy, Carolyn R, Chesterman, Colin N, Perry, Michael, Khachigian, Levon M

Journal:

Nature Biotechnology

Year:

2015

Language:

english

File:

PDF, 100 KB

english, 2015

6

Extracellular matrix is a source of mitogenically active platelet-derived growth factor

Susan L. Field, Levon M. Khachigian, Merilyn J. Sleigh, Guchen Yang, Sarah E. Vandermark, Philip J. Hogg, Colin N. Chesterman

Journal:

Journal of Cellular Physiology

Year:

1996

Language:

english

File:

PDF, 1.39 MB

english, 1996

7

Left main coronary artery stenosis after percutaneous transluminal coronary angioplasty: Importance of remaining “minimally invasive”

Harry C. Lowe, Colin N. Chesterman, Levon M. Khachigian

Journal:

Catheterization and Cardiovascular Interventions

Year:

1999

Language:

english

File:

PDF, 56 KB

english, 1999

8

Early growth response factor-1 mediates insulin-inducible vascular endothelial cell proliferation and regrowth after injury

Natalia Gousseva, Kumudhini Kugathasan, Colin N. Chesterman, Levon M. Khachigian

Journal:

Journal of Cellular Biochemistry

Year:

2001

Language:

english

File:

PDF, 407 KB

english, 2001

9

Antisense Egr-1 RNA driven by the CMV promoter is an inhibitor of vascular smooth muscle cell proliferation and regrowth after injury

Roger G. Fahmy, Levon M. Khachigian

Journal:

Journal of Cellular Biochemistry

Year:

2002

Language:

english

File:

PDF, 347 KB

english, 2002

10

von Hippel-Lindau tumor suppressor protein represses platelet-derived growth factor B-chain gene expression via the Sp1 binding element in the proximal PDGF-B promoter

Louise A. Rafty, Levon M. Khachigian

Journal:

Journal of Cellular Biochemistry

Year:

2002

Language:

english

File:

PDF, 149 KB

english, 2002

11

ERK, JNK, and p38 MAP kinases differentially regulate proliferation and migration of phenotypically distinct smooth muscle cell subtypes

Mary M. Kavurma, Levon M. Khachigian

Journal:

Journal of Cellular Biochemistry

Year:

2003

Language:

english

File:

PDF, 420 KB

english, 2003

12

Vascular smooth muscle cell-specific regulation of cyclin-dependent kinase inhibitor p21WAF1/Cip1 transcription by Sp1 is mediated via distinct cis-acting positive and negative regulatory elements in the proximal p21WAF1/Cip1 promoter

Mary M. Kavurma, Levon M. Khachigian

Journal:

Journal of Cellular Biochemistry

Year:

2004

Language:

english

File:

PDF, 323 KB

english, 2004

13

Suppression of growth factor expression and human vascular smooth muscle cell growth by small interfering RNA targeting EGR-1

Roger G. Fahmy, Levon M. Khachigian

Journal:

Journal of Cellular Biochemistry

Year:

2007

Language:

english

File:

PDF, 283 KB

english, 2007

14

Beyond angioplasty: novel developments in interventional cardiology

H. C. Lowe, D. Burkoff, L. M. Khachigian, B. D. MacNeill, M. Hayase, S. N. Oesterle

Journal:

Internal Medicine Journal

Year:

2002

Language:

english

File:

PDF, 413 KB

english, 2002

15

Intracoronary delivery of DNAzymes targeting human EGR-1 reduces infarct size following myocardial ischaemia reperfusion

Ravinay Bhindi, Roger G Fahmy, Aisling C McMahon, Levon M Khachigian, Harry C Lowe

Journal:

The Journal of Pathology

Year:

2012

Language:

english

File:

PDF, 1.32 MB

english, 2012

16

Activation transcription factor-4 and the acute vascular response to injury

Kristine P. Malabanan, Levon M. Khachigian

Journal:

Journal of Molecular Medicine

Year:

2010

Language:

english

File:

PDF, 206 KB

english, 2010

17

Emerging therapeutic approaches in the management of retinal angiogenesis and edema

An Truong, Tien Y. Wong, Levon M. Khachigian

Journal:

Journal of Molecular Medicine

Year:

2011

Language:

english

File:

PDF, 412 KB

english, 2011

18

Recent developments in drug-eluting stents

Yue Li, Ravinay Bhindi, Levon M. Khachigian

Journal:

Journal of Molecular Medicine

Year:

2011

Language:

english

File:

PDF, 157 KB

english, 2011

19

Early growth response factor 1: a pleiotropic mediator of inducible gene expression

L. M. Khachigian, Tucker Collins

Journal:

Journal of Molecular Medicine

Year:

1998

Language:

english

File:

PDF, 108 KB

english, 1998

20

Nucleic acid based strategies as potential therapeutic tools: mechanistic considerations and implications to restenosis

Fernando S. Santiago, Levon M. Khachigian

Journal:

Journal of Molecular Medicine

Year:

2001

Language:

english

File:

PDF, 97 KB

english, 2001

21

Immediate-early genes as master switches in disease

Levon Khachigian

Journal:

Cell Biology International

Year:

2008

Language:

english

File:

PDF, 38 KB

english, 2008

22

DNAzymes and their therapeutic possibilities

C. W. S. Chan, L. M. Khachigian

Journal:

Internal Medicine Journal

Year:

2009

Language:

english

File:

PDF, 129 KB

english, 2009

23

Phosphomannopentaose Sulfate (PI-88): Heparan Sulfate Mimetic with Clinical Potential in Multiple Vascular Pathologies

Levon M. Khachigian, Christopher R. Parish

Journal:

Cardiovascular Therapeutics

Year:

2004

Language:

english

File:

PDF, 95 KB

english, 2004

24

Vessel wall apoptosis and atherosclerotic plaque instability

M. M. KAVURMA, R. BHINDI, H. C. LOWE, C. CHESTERMAN, L. M. KHACHIGIAN

Journal:

Journal of Thrombosis and Haemostasis

Year:

2005

Language:

english

File:

PDF, 221 KB

english, 2005

25

DNAzymes targeting the transcription factor Egr-1 reduce myocardial infarct size following ischemia–reperfusion in rats

R. BHINDI, L. M. KHACHIGIAN, H. C. LOWE

Journal:

Journal of Thrombosis and Haemostasis

Year:

2006

Language:

english

File:

PDF, 367 KB

english, 2006

26

A monopartite sequence is essential for p45 NF-E2 nuclear translocation, transcriptional activity and platelet production

J. PERDOMO, E.-L. FOCK, G. KAUR, F. YAN, L. M. KHACHIGIAN, D. A. JANS, B. H. CHONG

Journal:

Journal of Thrombosis and Haemostasis

Year:

2010

Language:

english

File:

PDF, 1.08 MB

english, 2010

27

In vitro and in vivo proliferation, differentiation and migration of cardiac endothelial progenitor cells (SCA1+/CD31+ side-population cells)

S. X. LIANG, L. M. KHACHIGIAN, Z. AHMADI, M. YANG, S. LIU, B. H. CHONG

Journal:

Journal of Thrombosis and Haemostasis

Year:

2011

Language:

english

File:

PDF, 868 KB

english, 2011

28

Hemodynamics, Endothelial Gene Expression, and Atherogenesis

MICHAEL A. GIMBRONE JR., NITZAN RESNICK, TOBI NAGEL, LEVON M. KHACHIGIAN, TUCKER COLLINS, JAMES N. TOPPER

Journal:

Annals of the New York Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 752 KB

english, 1997

29

Catalytic Oligonucleotides Targeting EGR-1 As Potential Inhibitors of In-Stent Restenosis

LEVON M. KHACHIGIAN

Journal:

Annals of the New York Academy of Sciences

Year:

2001

Language:

english

File:

PDF, 158 KB

english, 2001

30

New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury

Santiago, Fernando S., Lowe, Harry C., Kavurma, Mary M., Chesterman, Colin N., Baker, Andrew, Atkins, David G., Khachigian, Levon M.

Journal:

Nature Medicine

Year:

1999

Language:

english

File:

PDF, 731 KB

english, 1999

31

10.1038/71020

Santiago, F.S, Lowe, H.C., Kavurma, M.M., Chesterman, C.N., Baker, A., Atkins, D.G., Khachigian, L.M.

Journal:

Nature Medicine

Year:

1999

Language:

english

File:

PDF, 34 KB

english, 1999

32

DNAzymes and cardiovascular disease

V L Benson, L M Khachigian, H C Lowe

Journal:

British Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 173 KB

english, 2008

33

Suppression of vascular permeability and inflammation by targeting of the transcription factor c-Jun

Fahmy, Roger G, Waldman, Alla, Zhang, Guishui, Mitchell, Ainslie, Tedla, Nicodemus, Cai, Hong, Geczy, Carolyn R, Chesterman, Colin N, Perry, Michael, Khachigian, Levon M

Journal:

Nature Biotechnology

Year:

2006

Language:

english

File:

PDF, 603 KB

english, 2006

34

Suppressing a sick heart

Khachigian, Levon M

Journal:

Nature Medicine

Year:

2005

Language:

english

File:

PDF, 466 KB

english, 2005

35

Transcription factor Egr-1 supports FGF-dependent angiogenesis during neovascularization and tumor growth

Fahmy, Roger G, Dass, Crispin R, Sun, Lun-Quan, Chesterman, Colin N, Khachigian, Levon M

Journal:

Nature Medicine

Year:

2003

Language:

english

File:

PDF, 1019 KB

english, 2003

36

Signaling and transcriptional control of Fas ligand gene expression

Kavurma, M M, Khachigian, L M

Journal:

Cell Death & Differentiation

Year:

2003

Language:

english

File:

PDF, 142 KB

english, 2003

37

Squamous cell carcinoma growth in mice and in culture is regulated by c-Jun and its control of matrix metalloproteinase-2 and -9 expression

Zhang, G, Luo, X, Sumithran, E, Pua, V S C, Barnetson, R St C, Halliday, G M, Khachigian, L M

Journal:

Year:

2006

Language:

english

File:

PDF, 374 KB

english, 2006

38

Mechanisms of angiotensin II-induced platelet-derived growth factor gene expression

Levon M. Khachigian, Yoh Takuwa, Tucker Collins

Journal:

Molecular and Cellular Biochemistry

Year:

2000

Language:

english

File:

PDF, 44 KB

english, 2000

39

Sp1, acetylated histone-3 and p300 regulate TRAIL transcription: Mechanisms of PDGF-BB-mediated VSMC proliferation and migration

Nor Saadah M. Azahri, Belinda A. Di Bartolo, Levon M. Khachigian, Mary M. Kavurma

Journal:

Journal of Cellular Biochemistry

Year:

2012

Language:

english

File:

PDF, 795 KB

english, 2012

40

DNAzymes as molecular agents that manipulate Egr-1 gene expression

Levon M Khachigian

Journal:

Biochemical Pharmacology

Year:

2004

Language:

english

File:

PDF, 68 KB

english, 2004

41

Dominantly Inherited Constitutional Epigenetic Silencing of MLH1 in a Cancer-Affected Family Is Linked to a Single Nucleotide Variant within the 5′UTR

Megan P. Hitchins, Robert W. Rapkins, Chau-To Kwok, Sameer Srivastava, Justin J.L. Wong, Levon M. Khachigian, Patsie Polly, Jack Goldblatt, Robyn L. Ward

Journal:

Year:

2011

Language:

english

File:

PDF, 1.62 MB

english, 2011

42

Succinobucol induces apoptosis in vascular smooth muscle cells

Robyn G. Midwinter, Ghassan J. Maghzal, Joanne M. Dennis, Ben J. Wu, Hong Cai, Alexandr A. Kapralov, Natalia A. Belikova, Yulia Y. Tyurina, Lan-Feng Dong, Levon Khachigian, Jiri Neuzil, Valerian E. Ka

Journal:

Free Radical Biology and Medicine

Year:

2012

Language:

english

File:

PDF, 862 KB

english, 2012

43

The role of c-jun in flow dependent and flow independent restenosis after angioplasty and stenting

M.J. Murrell, L. Khachigian, M.R. Ward

Journal:

Vascular Pharmacology

Year:

2006

Language:

english

File:

PDF, 51 KB

english, 2006

44

Injury-inducible yin yang-1 inhibits vascular smooth muscle cell growth and intimal thickening by repressing P21WAF1/CIP1 transcription and perturbing cyclin D1-CDK4-P21WAF1/CIP1 assembly

Fernando S. Santiago*, Hideto Ishii, Mark D. Hulett, Alexander Bobik, John F. Martin, Colin N. Chesterman, Ian C. Zachary, Levon M. Khachigian

Journal:

Vascular Pharmacology

Year:

2006

Language:

english

File:

PDF, 66 KB

english, 2006

45

Catalytic DNA as new drugs for vascular disease and cancer

Levon M. Khachigian

Journal:

Vascular Pharmacology

Year:

2012

Language:

english

File:

PDF, 63 KB

english, 2012

46

Rat aortic stenting: toward a simple model of in-stent restenosis

H.C Lowe, C.N Chesterman, L.M Khachigian

Journal:

The American Journal of Cardiology

Year:

2001

Language:

english

File:

PDF, 433 KB

english, 2001

47

Overstretch stent injury to the rat aorta leads to in-stent restenosis

H.C. Lowe, S.N. Oesterle, B.D. MacNeill, B. James, C.N. Chesterman, L.M. Khachigian

Journal:

The American Journal of Cardiology

Year:

2002

Language:

english

File:

PDF, 63 KB

english, 2002

48

Nuclear Factor-κB Mediates Induction of Vascular Cell Adhesion Molecule-1 in Glomerular Mesangial Cells

L.M. Khachigian, T. Collins, J.W.U. Fries

Journal:

Biochemical and Biophysical Research Communications

Year:

1995

File:

PDF, 350 KB

1995

49

Genistein inhibits PDGF-stimulated proteoglycan synthesis in vascular smooth muscle without blocking PDGFβ receptor phosphorylation

Peter J. Little, Robel Getachew, Hossein Babaahmadi Rezaei, Estella Sanchez-Guerrero, Levon M. Khachigian, Haitao Wang, Sufen Liao, Wenhua Zheng, Mandy L. Ballinger, Narin Osman

Journal:

Archives of Biochemistry and Biophysics

Year:

2012

Language:

english

File:

PDF, 624 KB

english, 2012

50

Platelet-Derived Growth Factor-BB Mediates Cell Migration through Induction of Activating Transcription Factor 4 and Tenascin-C

Kristine P. Malabanan, Anjali V. Sheahan, Levon M. Khachigian

Journal:

The American Journal of Pathology

Year:

2012

Language:

english

File:

PDF, 1.36 MB

english, 2012

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